I study the structural biology of phospholipase C epsilon (PLCε), a signaling protein frequently dysregulated in cancers. This work is part of a larger effort in the Falzone lab to understand the regulatory role of phospholipases in cellular signaling pathways and how these mechanisms may eventually be targeted therapeutically.

My most recent role was as a software engineer at Hack Club Bank, where I was part of a small team of developers that helped build a financial platform for students and nonprofits to raise and manage finances transparently. Before that, I was a designer-developer at Hack Club, where I helped build tools and experiences for students to build projects and learn to code.

I attended the University of Texas at San Antonio, where I earned a BS in biochemistry and focused on biosynthetic organic chemistry and computational biophysics. I am grateful to have gotten my start in research in an organic chemistry group on campus. I also learned small molecule X-ray crystallography from Dr. Hadi Arman at that time. After those experiences, I continued my research career working with Dr. Maria Falzone and Dr. Rahul Mojidra on the structure and function of PLCε using cryo-electron microscopy and fluorescence spectroscopy. For my thesis, I worked on mathematical methods for estimating protein rigidity from density maps. I was co-advised by Dr. Hadi Arman for this work.
Matrix-Based Protein–Protein Interaction Screening and Region-Aware Interface Analysis Mohanty, S.1,2,3,4 (2026), software
Functional Characterization of PLCε Catalytic Activities
Mohanty, S.1,2,3,4, Mojidra, R.2,3, & Falzone, M.2,3,4 (2026), poster
A Reproducible Web Workflow for Plate-Reader Data Normalization, Kinetic Modeling, and Reporting Mohanty, S.1,2,3,4 (2025), software
Optimization of Full-Length PLCε Purification to Enable Studies of Ras-Mediated Oncogenic Signaling
Mohanty, S.1,2, Mojidra, R.2,3, & Falzone, M.2,3,4 (2025), poster
Formal Languages and Compiler Tools for Burden-Aware Genetic Circuit and Pathway Design
Mohanty, S.1 (2025), proposal
A Telemetry Pipeline for Quantitative Longitudinal Pattern Tracking in Chemical Education Mohanty, S.1 (2025), software
1Department of Chemistry, University of Texas at San Antonio, 2Department of Biochemistry and Structural Biology, UT Health Science Center San Antonio, 3Greehey Children's Cancer Research Institute, San Antonio, TX, 4Mays Cancer Center, San Antonio, TX
hello [at] sarthakmohanty [dot] me